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Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]

Pharmacological rescue of carnitine transport in primary carnitine deficiency

Abdel-Moneim AM, Al-Kahtani MA, El-Kersh MA, Al-Omair MA

Of note, the NCCD suggests avoiding the term eryptosis due to the complexity and disputability of the life/death status of mature erythrocytes, notwithstanding the emphasis on its physiological and pathophysiological importance [4]

Human PMSCs were able to improve ovarian function and follicular development in autoimmune POF mice by inhibiting the overactivation of the inositol-requiring enzyme 1 signaling pathway and reducing granulosa cell apoptosis [121]